The Role of OCTA in Evaluating Diabetic Retinopathy Progression: A Meta-Analysis.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Alternative therapies in health and medicine Pub Date : 2024-08-01

Lei Xi, Minfang Fan, Longhao Kuang, Feng Zhao

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引用次数: 0

Abstract

Background: Diabetic retinopathy (DR) substantially threatens ocular health, necessitating the accurate and prompt assessment of its onset and progression. Optical coherence tomography angiography (OCTA) is a valuable tool for evaluating periocular microvascular indicators, offering insights crucial for diagnosing and treating DR.

Objective: This meta-analysis aims to evaluate the progression of diabetic retinopathy (DR) by examining periocular microvascular indicators using optical coherence tomography angiography (OCTA). The objective is to provide substantive evidence for the future diagnosis and treatment of DR.

Methods: We analyzed the relevant research retrieved from PubMed and Web of Science until January 2023. The inclusion and exclusion criteria were carefully applied to select eligible studies. Quality assessment was performed using the Newcastle-Ottawa Scale, with studies scoring 4 or less excluded. Meta-analysis was conducted using Revman 5.3 software and focused on key indicators, including peripapillary vascular length density (pVLD) and peripapillary vascular density (pVD). Heterogeneity was assessed using I2 and P values, with effect sizes determined via fixed-effect or random-effects models based on heterogeneity levels.

Results: Six studies involving 839 DR-afflicted eyes and 3209 non-DR eyes were included after screening. All selected articles exhibited high reference value, with quality scores ranging from 5 to 8 points. The meta-analysis demonstrated that DR patients displayed significantly lower pVD and pVLD in the superficial (SCP) and deep capillary plexus (DCP) compared to non-DR patients (P < .05). These findings remained consistent across different effect models, reaffirming their validity.

Conclusions: Patients with DR exhibit reduced levels of pVD and pVLD in the SCP and DCP compared to non-DR individuals. OCTA examination of periocular microvascular indicators emerges as an effective tool for assessing the onset and progression of DR.

本刊更多论文

OCTA在评估糖尿病视网膜病变进展中的作用:一项meta分析。

背景:糖尿病视网膜病变(DR)严重威胁眼部健康，需要准确和及时地评估其发病和进展。光学相干断层扫描血管成像(OCTA)是评估眼周微血管指标的一种有价值的工具，为DR的诊断和治疗提供了重要的见解。目的:本荟萃分析旨在通过光学相干断层扫描血管成像(OCTA)检查眼周微血管指标来评估糖尿病视网膜病变(DR)的进展。目的是为dr的未来诊断和治疗提供实质性证据。方法:我们分析了截至2023年1月PubMed和Web of Science检索的相关研究。仔细应用纳入和排除标准来选择符合条件的研究。使用纽卡斯尔-渥太华量表进行质量评估，排除4分或以下的研究。采用Revman 5.3软件对关键指标乳头周围血管长度密度(pVLD)和乳头周围血管密度(pVD)进行meta分析。使用I2和P值评估异质性，通过基于异质性水平的固定效应或随机效应模型确定效应大小。结果:筛选后纳入6项研究，涉及839只dr眼和3209只非dr眼。所有入选的文章都具有很高的参考价值，质量得分在5到8分之间。meta分析显示，DR患者的浅毛细血管丛(SCP)和深毛细血管丛(DCP)的pVD和pVLD明显低于非DR患者(P < 0.05)。这些发现在不同的效应模型中保持一致，重申了它们的有效性。结论:与非DR患者相比，DR患者在SCP和DCP中表现出较低的pVD和pVLD水平。OCTA检查眼周微血管指标是评估DR发病和进展的有效工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

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