Pathology of adenocarcinoma of the corpus uteri induced by inoculation with transplantable carcinomas of the stomach, the colon and the corpus uteri in Wistar-Furth Osaka rat strain.

Abstract

Among 659 female recipient rats inoculated with the transplantable carcinomas of the stomach (S1 and S3), the colon (C1 and C2) and the corpus uteri (U2) in the same strain of Wistar-Furth Osaka (WF Osaka) rats, 160 adenocarcinomas of the corpus uteri were found. 79 cases of them were grossly diagnosed as carcinomas, because the uteri were tremendously enlarged and kinking in the peritoneal cavity. The rest of them were confirmed to be carcinomas histologically. They were all well differentiated tubular adenocarcinomas with some papillary growth in the uterine cavity. Only one case showed to be an invasive carcinoma. Average age of female rats at the time of inoculation was 42 days after birth, and the uterine carcinomas were found in 34 days in average thereafter. Such carcinomas of the corpus uteri in young adolescent female rats have not been seen, excluded the cases inoculated with those transplantable tumors mentioned above into the peritoneal cavity on this WF Osaka rat strain. Therefore, it was thought that each transplantable carcinoma had played an important role for the induction of the adenocarcinoma of the corpus uteri.