Comprehensive prognostic signatures in thyroid cancer: A summarized review for molecular signatures construction strategies

Gene & protein in disease Pub Date : 2023-09-20 DOI:10.36922/gpd.1138

Xiaoyan Lu, Yuanyuan Zhang, Pei Yang, Minjun Yi, Luyao Wang, Jing Chen, Han Wang, Mengke Li, Yufei Jiang, Bingbing Guo, Wenyuan Lu, Shijia Li, Jiahao Chen, Yingying Lian, Xinyu Li, Binbin Zhao, Xiaoqing Wang, Yang An

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Abstract

Thyroid carcinoma (TC) is one of the most common endocrine carcinomas with an increasing rate of morbidity in recent decades. With a high risk of relapse and metastasis occurring in TC patients, it is essential to identify potential prognostic signatures for TC patients. Here, through a comprehensive review, we summarized 45 prognostic signatures for TC patients and concluded three main strategies for signature establishment after an extensive investigation. In particular, these signatures were classified according to different construction strategies, and the verification methods were summarized. Besides, we found that 18 key genes were overrepresented in reported signatures. This review provides a comprehensive understanding, systematic summary, and integrated analysis of current prognostic signatures of TC, which may help researchers to further understand cancer progression, construct prognostic signatures of TC, and guide future clinical treatment.

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甲状腺癌的综合预后特征:分子特征构建策略综述

甲状腺癌(TC)是最常见的内分泌癌之一，近几十年来发病率不断上升。由于TC患者复发和转移的风险很高，因此确定TC患者的潜在预后特征至关重要。在这里，通过全面的回顾，我们总结了45个TC患者的预后特征，并在广泛的调查后得出了三种主要的特征建立策略。根据不同的构造策略对这些签名进行了分类，并对验证方法进行了总结。此外，我们发现18个关键基因在报告的签名中被过度代表。本综述对目前TC的预后特征进行了全面的认识、系统的总结和综合分析，有助于研究人员进一步了解肿瘤进展，构建TC的预后特征，指导临床治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gene & protein in disease

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