Strategies of acellular graft scaffold approaches as alternatives to tissue regeneration

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-10 DOI:10.1680/jbibn.22.00072

Diana Sofía Nolasquez-Cruz, Héctor Flores, Amaury de Jesús Pozos-Guillen, Marco Antonio Alvarez-Perez

引用次数: 0

Abstract

Autologous grafts represent the gold standard for regenerated tissues after diseases, trauma or defects. However, the main problems of this strategy are availability, donor site morbidity and postoperative complications. For this reason, a new approach in tissue engineering looks at scaffolds obtained through the decellularization of native extracellular matrices as an alternative technology to circumvent these limitations. Thus, this review aims to focus on the potential for use of acellular grafts, particularly on the methods of decellularization and recellularization, and continues with their application as part of the formulation of bioinks, which would represent a breakthrough in the field of biofabrication due to their naturally bioactive composition, preserving tissue architecture and structural integrity as a potential alternative for tissue regeneration.

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脱细胞支架移植方法替代组织再生的策略

自体移植物是疾病、创伤或缺陷后再生组织的金标准。然而，这种策略的主要问题是可用性、供区发病率和术后并发症。出于这个原因，组织工程中的一种新方法着眼于通过天然细胞外基质的脱细胞化获得支架，作为规避这些限制的替代技术。因此，本综述旨在关注脱细胞移植物的应用潜力，特别是脱细胞和再细胞方法，并继续将其作为生物墨水配方的一部分应用，这将是生物制造领域的一个突破，因为它们具有天然的生物活性成分，保留了组织结构和结构完整性，是组织再生的潜在替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.