Extramedullary plasmacytoma of the larynx – Case report

IF 1.4 4区医学 Q4 ONCOLOGY

Journal of cancer research and therapeutics Pub Date : 2023-09-21 DOI:10.4103/jcrt.jcrt_1640_20

Ajinkya Gupte, Ajay Sasidharan, Debnarayan Dutta, R Anoop

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引用次数: 0

Abstract

ABSTRACT Extramedullary plasmacytoma of the larynx is an extremely rare entity accounting for 0.04–0.45% of malignant tumours of the larynx. The objective of this clinical case report is to highlight the diagnosis and management of a unique case such as this. A 77-year-old gentleman presented with complaints of hoarseness for 1 year. Computed tomography image revealed a soft tissue mass lesion involving the right true vocal cord. Direct laryngoscopic biopsy was performed and subjected to histopathological examination, which showed collection of plasma cells. Immunohistochemistry confirmed the presence of Kappa and Lambda cells. Multiple myeloma (MM) was ruled out. The patient received radical intent radiation therapy using 3DCRT technique with a dose of 50Gy in 25# over 5 weeks. He experienced improvement in hoarseness on subsequent follow-up visits. At 1-year follow up, positron emission tomography computed tomography showed near total resolution of disease with no progression to MM. Radiation therapy alone is known to achieve good local control, recurrence free survival, and organ preservation in such cases.

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喉髓外浆细胞瘤1例

喉髓外浆细胞瘤是一种极为罕见的肿瘤，约占喉恶性肿瘤的0.04-0.45%。本临床病例报告的目的是强调诊断和管理的一个独特的情况下，如这。一位77岁的男士以声音嘶哑1年为主诉。计算机断层扫描图像显示软组织肿块病变累及右侧真声带。直接喉镜活检，组织病理检查，显示收集浆细胞。免疫组化证实Kappa和Lambda细胞的存在。排除多发性骨髓瘤(MM)。患者采用3DCRT技术进行根治性放疗，剂量50Gy, 25#， 5周。在随后的随访中，他的声音嘶哑有所改善。在1年的随访中，正电子发射断层扫描显示疾病几乎完全消退，没有进展为MM。在这种情况下，单独放疗可以获得良好的局部控制，无复发生存和器官保存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of cancer research and therapeutics ONCOLOGY-

CiteScore

1.80

自引率

15.40%

发文量

299

审稿时长

6 months

期刊介绍： The journal will cover technical and clinical studies related to health, ethical and social issues in field of Medical oncology, radiation oncology, medical imaging, radiation protection, non-ionising radiation, radiobiology. Articles with clinical interest and implications will be given preference.