Identification of DNA repair gene signature and potential molecular subtypes in hepatocellular carcinoma

Abstract

DNA repair is a critical factor in tumor progression since it influences tumor mutational burden, genome stability, PD-L1 expression, tumor-infiltrating lymphocytes (TILs) and immunotherapy response. In this study, we constructed a prognostic model for hepatocellular carcinoma (HCC) based on DNA damage response (DDR)-related genes.