The Effects of Vitamin D Supplementation on glycemic indices, lipid profile and blood pressure of pregnant women with Vitamin D deficiency: A Single arm Clinical Trial

IF 0.3 Q4 OBSTETRICS & GYNECOLOGY

Current Women s Health Reviews Pub Date : 2023-08-18 DOI:10.2174/1573404820666230818092734

Seyedeh Razieh Hashemi, Arezoo Esmailzadeh, Mahboobeh Sadat Hosseini, Sepideh Abbaszadeh, Maryam Taghdir, Simindokht Esmailzadeh, Tahereh Babashamsi, Saeideh Nahani

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引用次数: 0

Abstract

Introduction: Vitamin D Deficiency (VDD) is a global problem among pregnant women in many populations. There is an association between VDD and some pregnancy outcomes, as well as gestational diabetes mellitus (GDM) and pre-eclampsia. We aimed to evaluate the effect of vitamin D supplementation on metabolic status (Fasting Blood Sugar (FBS), insulin, Homeostasis model of assessment-insulin resistance (HOMA-IR) and lipid profile) and blood pressure (BP) among pregnant women with VDD. Methods: A clinical trial was carried out on 30 pregnant women with VDD referring to the Gynecology & Obstetrics Clinic of Baqiyatallah Hospital, Tehran, Iran. The present study had two phases of vitamin D3 supplementation (50000 IU / week for 12 weeks and then 50000 IU / month for three months). Serum total cholesterol, triglyceride, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), 25-hydroxyvitamin D (25(OH) D) level, insulin, Fasting Blood Sugar (FBS) and both systolic and diastolic blood pressure were measured. Homeostasis model of assessment-insulin resistance (HOMA-IR) was also determined. Results: The results showed that mean levels of Insulin (F=6, p=0.010), HOMA-IR (F=4.6, p=0.020), 25-hydroxyvitamin D level (F=179, p=0.001), cholesterol (F=69.7, p=0.001), triglyceride (F=69.9, p=0.001) and LDL (F=29.9, p=0.001) significantly increases during study period. However, Diastolic and systolic blood pressure, FBS, and HDL levels did not change significantly over time. Conclusion: The results of this investigation showed that weekly and monthly vitamin D3 supplementation in pregnant women with VDD had beneficial effects on glycemic status, lipid profile and blood pressure. Trial registration: The protocol of the present study has been registered in IRCT (Registration number: IRCT2014091619162N5, Registration date: 2015-03-26, https://en.irct.ir/trial/17219).

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补充维生素D对维生素D缺乏孕妇血糖指数、血脂和血压的影响:一项单臂临床试验

维生素D缺乏症(VDD)是许多人群中孕妇的一个全球性问题。VDD与某些妊娠结局、妊娠期糖尿病(GDM)和先兆子痫之间存在关联。我们的目的是评估补充维生素D对VDD孕妇代谢状态(空腹血糖(FBS)、胰岛素、稳态评估模型-胰岛素抵抗(HOMA-IR)和血脂)和血压(BP)的影响。方法:对30例妊娠期VDD患者进行临床研究。伊朗德黑兰，Baqiyatallah医院产科诊所。本研究分为两个阶段补充维生素D3(每周50000 IU，持续12周，然后每月50000 IU，持续3个月)。测定血清总胆固醇、甘油三酯、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、25-羟基维生素D (25(OH) D)水平、胰岛素、空腹血糖(FBS)、收缩压和舒张压。评估胰岛素抵抗的稳态模型(HOMA-IR)也被确定。结果:研究期间胰岛素(F=6, p=0.010)、HOMA-IR (F=4.6, p=0.020)、25-羟基维生素D (F=179, p=0.001)、胆固醇(F=69.7, p=0.001)、甘油三酯(F=69.9, p=0.001)、低密度脂蛋白(F=29.9, p=0.001)的平均水平显著升高。然而，舒张压和收缩压、FBS和HDL水平没有随时间发生显著变化。结论:本研究结果表明，每周和每月补充维生素D3对VDD孕妇的血糖、血脂和血压有有益的影响。试验注册:本研究方案已在IRCT中注册(注册号:IRCT2014091619162N5，注册日期:2015-03-26,https://en.irct.ir/trial/17219)。

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来源期刊

Current Women s Health Reviews OBSTETRICS & GYNECOLOGY-

CiteScore

0.70

自引率

25.00%

发文量

期刊介绍： Current Women"s Health Reviews publishes frontier reviews on all the latest advances on obstetrics and gynecology. The journal"s aim is to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all clinicians and researchers in the fields of obstetrics and gynecology.