Characterization of the blood coagulation system in morbidly obese patients

Q4 Biochemistry, Genetics and Molecular Biology

Ukrainian Biochemical Journal Pub Date : 2023-09-11 DOI:10.15407/ubj95.04.003

D. S. Korolova, O. V. Hornytska, A. S. Lavrik, N. M. Druzhyna, N. Prysyazhna, T. M. Platonova

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Abstract

Obesity is a complex metabolic disorder that can be followed by blood coagulation disorders, atherosclerosis and atherothrombosis. In the present work, the levels of fibrinogen, soluble fibrin, D-dimer as well as protein C were measured in the blood plasma of 24 morbidly obese patients (the body mass index exceeds 40 kg/m2) to evaluate the risk of prothrombotic state. The study showed that near by 80% of patients had substantially increased fibrinogen concentration, 33% had increased concentration of soluble fibrin, 42% had increased level of D-dimer in blood plasma as compared to control. According to the results of individual analysis, the high level of fibrinogen and soluble fibrin while reduced protein C indicated the threat of thrombosis, which requires complex diagnostics to be identified. Therefore, simultaneous quantification of hemostatic system biomarkers in the blood plasma is the confident way to predict the risk of thrombotic complications in morbidly obese patients. Keywords: D-dimer, hemostasis, obesity, protein C, soluble fibrin, thrombosis

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病态肥胖患者凝血系统的特征

肥胖是一种复杂的代谢紊乱，随之而来的可能是凝血障碍、动脉粥样硬化和动脉粥样硬化血栓形成。本研究通过测定24例病态肥胖患者(体重指数超过40 kg/m2)血浆中纤维蛋白原、可溶性纤维蛋白、d -二聚体和蛋白C的水平，评价血栓形成前状态的危险性。研究表明，与对照组相比，近80%的患者血浆纤维蛋白原浓度显著升高，33%的患者血浆可溶性纤维蛋白浓度升高，42%的患者血浆d -二聚体水平升高。根据个体分析结果，纤维蛋白原和可溶性纤维蛋白水平高，蛋白C降低，提示血栓形成的威胁，需要复杂的诊断来识别。因此，同时定量血浆中的止血系统生物标志物是预测病态肥胖患者血栓并发症风险的可靠方法。关键词:d -二聚体，止血，肥胖，蛋白C，可溶性纤维蛋白，血栓形成

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来源期刊

Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.