Echinomycin: A Journey of Challenges

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-09-23 DOI:10.35516/jjps.v16i3.918

Zainab Lafi, Walhan Alshaer, Ma’mon M. Hatmal, Malek A. Zihlif, Nisreen Y. Asha, Hiba Abdelnabi, Abdullah Awidi

引用次数: 0

Abstract

Echinomycin is a natural compound discovered and isolated from bacteria, introduced as a promising antibiotic and anticancer therapy. However, it failed clinically due to improper formulations and a short half-life. After the unsuccessful clinical trials, echinomycin was overlooked. Recently, a new mechanism of action has given some hope for reviving echinomycin as an inhibitor of hypoxia-inducible factor (HIF-1). In 2015, echinomycin received orphan drug designation for treating acute myeloid leukemia in the USA. Furthermore, advancements in drug delivery systems have provided new prospects to overcome the echinomycin formulation issues and explore further therapeutic benefits. This review details the echinomycin journey along with the main challenges of this potent drug and provides insights into possible future clinical applications.

查看原文本刊更多论文

紫霉素:挑战之旅

棘霉素是一种从细菌中分离出来的天然化合物，是一种很有前途的抗生素和抗癌药物。但由于配方不当，半衰期短，临床失败。在临床试验不成功后，棘霉素被忽视。最近，一种新的作用机制为恢复棘霉素作为缺氧诱导因子(HIF-1)抑制剂的作用带来了希望。2015年，青霉霉素在美国被认定为孤儿药，用于治疗急性髓性白血病。此外，药物传递系统的进步为克服青霉霉素的配方问题和探索进一步的治疗效益提供了新的前景。这篇综述详细介绍了青霉霉素的历程以及这种强效药物的主要挑战，并为未来可能的临床应用提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.