Whole Exome Sequence of Pakistani Acute Lymphocytic Leukemia Patient from Pakhtuns Ancestry Reveal the Novel Genetic Variant Characterization in the GLDC Gene

Abstract

Background: Acute Lymphoblastic Leukemia (ALL) is the most common malignant disease in children and often involves numerical chromosomal abnormalities, fusion genes, or minor localized deletions that are significant in the development of leukemia. Glycine Decarboxylase (GLDC) gene overexpression and mutation is associated with oncogenic activity in various cancers. However, the pathophysiological roles and structural consequences of GLDC in acute lymphocytic leukemia have not been investigated.