Determining the Necessary Amount and Dosage of Using Antioxidants in the Pregnant Women with Obesity to Prevent Adverse Outcomes Arise from Oxidative Stress

Abstract

Normal gestational development depends on adequate nutrients and oxygen transportation in the circuit of mother-placenta-fetus. In the obese mothers, fetal growth alterations and increased risk of Large for gestational age delivering are relevant to excess in the nutrient supply. Obese mothers have also an increased risk for Small for gestational age deliveries. Small for gestational age and Large for gestational age are associated with perinatal complications like stillbirth and later complications during life span. Placental overgrowth along with increased amounts of nutrients and oxygen flux, would result in Large for gestational age newborns which during the life span, such Large for gestational age children would present themselves with more Oxidative stress and Insulin resistance in comparison with Appropriate for gestational age children.