Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2023-10-18 DOI:10.1002/hlca.202300143

Nicholas A. Isley, Fabrice Gallou

引用次数: 0

Abstract

A scalable and environmentally benign protocol for a Suzuki–Miyaura cross-coupling in water using vitamin E derived surfactant TPGS-750-M is reported. The protocol is the most simple and standard for such transformations under micellar catalysis that has been amply utilized within our own research and development portfolio over the last decade. The impact of the synthetic procedure is reenforced by green Process Mass Intensity and Total Carbon Release metrics.

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利用胶束催化通过Suzuki-Miyaura交叉偶联合成4 -氯- 6 -(6 -甲氧基吡啶- 3 -基)嘧啶

摘要:本文报道了一种可扩展的、环境友好的、使用维生素E衍生表面活性剂TPGS‐750‐M在水中进行Suzuki-Miyaura交叉偶联的方案。该协议是在胶束催化下进行此类转化的最简单和最标准的协议，在过去十年中已在我们自己的研究和开发组合中得到充分利用。合成过程的影响通过绿色过程质量强度和总碳释放得到加强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.