Effect of Chemostat Turnover Rate and Select Antibiotics on Salmonella Typhimurium in the Presence of Porcine Gastrointestinal Tract Bacteria

IF 1.2 4区 农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE
R.C. Anderson, T.L. Poole, T.C. Crippen, Roger B. Harvey, Steven Ricke
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引用次数: 0

Abstract

The effect of select antibiotics on Salmonella Typhimurium DT104 persistence in a porcine cecal continuous flow culture was examined under two different washout rates. Porcine continuous flow cultures were conducted in the presence or absence of gram-positive antibiotic carbadox. Carbadox eliminated chemostat anaerobes culturable on Brucella agar under 24 h turnover conditions, allowing Salmonella Typhimurium to persist for 15 days. Decreasing the culture dilution rate from a 24 to 48 h turnover time enabled Salmonella Typhimurium to maintain higher population levels more reflective of the theoretical washout rate when grown with than without added carbadox. This observation suggests that at the slower growth rate the presence of carbadox was antagonistic to the indigenous competitive exclusion potential of the mixed microbial population.
猪胃肠道细菌存在情况下鼠伤寒沙门菌抑化剂转化率及抗菌药物选择的影响
在两种不同的冲洗率下,研究了几种抗生素对鼠伤寒沙门菌DT104在猪盲肠连续流培养中的持久性的影响。在存在或不存在革兰氏阳性抗生素卡多克斯的情况下进行猪连续流培养。卡巴多在24小时的周转条件下消除了在布鲁氏菌琼脂上培养的抑化厌氧菌,使鼠伤寒沙门菌存活了15天。将培养稀释率从24小时降低到48小时,使鼠伤寒沙门菌在添加卡多克斯的情况下比不添加卡多克斯的情况下保持较高的种群水平,这更能反映理论冲洗率。这一观察结果表明,在较慢的生长速度下,卡多克斯的存在对混合微生物群体的本地竞争排斥潜力是拮抗的。
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来源期刊
Canadian Journal of Animal Science
Canadian Journal of Animal Science 农林科学-奶制品与动物科学
CiteScore
2.30
自引率
0.00%
发文量
51
审稿时长
6 months
期刊介绍: Published since 1957, this quarterly journal contains new research on all aspects of animal agriculture and animal products, including breeding and genetics; cellular and molecular biology; growth and development; meat science; modelling animal systems; physiology and endocrinology; ruminant nutrition; non-ruminant nutrition; and welfare, behaviour, and management. It also publishes reviews, letters to the editor, abstracts of technical papers presented at the annual meeting of the Canadian Society of Animal Science, and occasionally conference proceedings.
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