Review—Prospects in Cancer Diagnosis: Exosome-Chip for Liquid Biopsy

Abstract

Abstract A liquid biopsy combined with an exosome chip is an important detection tool for early cancer diagnosis. Exosomes have a crucial function in the exchange of information between cells and are present in biological fluids. Exosome chips are microfluidic devices designed to isolate, capture, and analyze exosomes for analysis of patient samples. These offer on-chip detection, high-throughput analysis, and multiplex measurements. Such chips can integrate with electrochemical and optical detectors, and mass spectrometry enabling comprehensive studies of diseases. This perspective will cover the outlook on chip-based diagnostics for liquid biopsy, detection, and isolation of exosomes to support cancer diagnostics.