The effect of cigarette smoke exposure on rat’s spermatogenesis: A systematic literature review and meta-analysis

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-11-02 DOI:10.1177/1721727x231207720

Tena Djuartina, Iskandar Rahardjo Budianto, Andreas Steven, Maria Stefani, Melani Kawilarang, Melisa Kawilarang

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Abstract

Objective: To conduct a systematic review and meta-analysis of all available published data related to rats about spermatogenesis to provide a comprehensive overview of the effects of cigarette smoke exposure on the parameters of spermatogenesis.Methods: A comprehensive search of electronic databases including PubMed, EBSCO, ProQuest, Science Direct, Taylor & Francis, Springer Link, GARUDA, and Google Scholar, spanning from their inception until January 29th, 2021, was conducted to retrieve relevant studies and full-text articles evaluating the effect of cigarette smoke exposure on the parameters of spermatogenesis in rats. Data were taken from eligible studies. We use SYRCLE’s Risk of Bias tool for this animal studies. The overall size effect was measured, and forest plots and funnel plots were generated using the statistical software JASP.Results: The present study comprised 23 studies involving 527 rats. The findings of this meta-analysis revealed that parameters of spermatogenesis, such as sperm count, morphology, and viability, were substantially impaired in response to conventional cigarette smoke exposure, exhibiting and aggregate correlation coefficient of 0,70 (95% CI:0.61-0.79, p < .001).Conclusion: Exposure to conventional cigarette smoke has a significant negative effect on spermatogenic parameters in rats, particularly in terms of sperm count, morphology, and viability.

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香烟烟雾暴露对大鼠精子发生的影响:系统文献综述和荟萃分析

目的:对所有已发表的与大鼠精子发生有关的数据进行系统回顾和荟萃分析，以全面概述吸烟对精子发生参数的影响。方法:综合检索PubMed、EBSCO、ProQuest、Science Direct、Taylor &Francis, Springer Link, GARUDA和Google Scholar从成立到2021年1月29日，检索了评估香烟烟雾暴露对大鼠精子发生参数影响的相关研究和全文文章。数据取自符合条件的研究。我们使用sycle的风险偏倚工具进行动物研究。测量总体规模效应，利用统计软件JASP生成森林图和漏斗图。结果:本研究共纳入23项研究，527只大鼠。这项荟萃分析的结果显示，精子发生的参数，如精子数量、形态和活力，在传统的香烟烟雾暴露中受到严重损害，显示出和总体相关系数为0.70 (95% CI:0.61-0.79, p <措施)。结论:暴露于传统香烟烟雾对大鼠的生精参数有显著的负面影响，特别是在精子数量、形态和活力方面。

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来源期刊

European Journal of Inflammation Medicine-Immunology and Allergy

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期刊介绍： European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.