The Association of Platelet Index with Event of Deep Vein Thrombosis in Acute Ischemic Stroke Patients at Rumah Sakit Umum Pusat Haji Adam Malik Medan

Abstract

Introduction: Deep Vein Thrombosis (DVT) occurs in stroke with an incidence varying from 10-75%, depending on the diagnostic method and time of evaluation. Platelets play important role in the pathogenesis of thromboembolism. Large size platelets are more metabolically and enzymatically active also hemostatically more reactive and prone to the development of thrombosis. This study aims to determine the association between platelet index and the occurrence of DVT in patients with acute ischemic stroke. Method: Prospective study with a total of 42 samples acute ischemic stroke patients who were treated ≤ 3 days in the stroke corner of RSUP. H Adam Malik Medan. Compression ultrasonography to diagnose DVT was performed on the lower extremities. Platelet indices assessed were mean platelet volume (MPV), platelet volume distribution width (PDW), and plateletcrit (PCT) based on the results of a complete blood test on admission. Results: The mean age was 59.7 years with male gender as much as 66.7%. The majority of research subjects had a history of hypertension (42.9%) The mean body mass index was 28, 18 kg/mm2. 97.6% were found to have asymptomatic DVT with Well's score of 1 (moderate probability of DVT occurrence). 54.8% of the study subjects with positive DVT results based on compression ultrasound results. There is an association between increased MPV and the incidence of DVT in acute ischemic stroke patients (p = 0.002). Conclusion: There is an association between an increase in MPV value and the incidence of DVT in acute ischemic stroke patients. Keywords: Platelet Index, Deep Vein Thrombosis, Acute Ischemic Stroke, Mean Platelet Volume, Platelet Distribution Width, Plateletcrit