(Betaine: Citric Acid: H2O) a Natural Deep Eutectic Solvent (NaDES)-Mediated Efficient and Green Synthesis of 4-Benzylidene Isoxazol-5-one Derivatives

IF 2.4 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-09-13 DOI:10.1080/10406638.2023.2261594

引用次数: 0

Abstract

A biodegradable catalyst based on natural deep eutectic solvents (NaDESs) designed from Betaine and natural acids (Betaine: Citric Acid: H2O) with a molar ratio of (1:1.5:1) has been utilized in one-pot multi-component reaction for the synthesis of Isoxazol-5-ones derivatives in a mild, green and efficient manner. The reaction was carried out under different conditions that are, at 40⁰C, ultrasonic and microwave. The developed method provided many advantages, including an excellent yield of up to 98% in a shorter reaction time, avoiding the use of toxic solvents and an easy handling process. Additionally, the use of NaDESs enabled the conservation of resources due to their simple preparation. The developed process adheres to the requirements of green chemistry by employing a bio-sourced and recyclable catalyst.

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(甜菜碱：柠檬酸：水）天然深共晶溶剂 (NaDES) 促进了 4-亚苄基异恶唑-5-酮衍生物的高效绿色合成

一种基于天然深共晶溶剂（NaDESs）的可生物降解催化剂，由甜菜碱和天然酸（甜菜碱：柠檬酸：H2O）设计而成，摩尔比为（1:1.5:1），被用于一锅多组分反应，以温和、绿色和高效的方式合成异恶唑-5-酮衍生物。反应在不同条件下进行，包括 400℃、超声波和微波。所开发的方法具有许多优点，包括在较短的反应时间内获得高达 98% 的高产率，避免了有毒溶剂的使用，以及操作过程简便。此外，由于制备简单，使用 NaDES 可以节约资源。所开发的工艺采用了生物来源和可回收的催化剂，符合绿色化学的要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.