Gut microbiome-based dietary intervention in Parkinson disease subject: A case report

Q4 Medicine

International Journal of Nutrition, Pharmacology, Neurological Diseases Pub Date : 2023-07-01 DOI:10.4103/ijnpnd.ijnpnd_8_23

Ayesha Sulthana, Shasthara Paneyala, Sindhu H.S., Meghana Kowlagi Narayan, Tousif Ahmed Hediyal, Sonali Sharma, Arunsaikiran Senthilkumar, Paul Dave, Arehally M. Mahalakshmi, Saravana Babu Chidambaram, Tanya M. Monaghan, Dinanath Sulakhe

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引用次数: 0

Abstract

A 54-year-old woman was seeking medical treatment for Parkinson disease (PD) in the neurology outpatient department in JSS Hospital, Mysore, India. She was challenged in terms of reduced mobility and had sought several treatment options to control her PD symptoms without successful outcome. After examination and confirmation of diagnosis, the decision was taken to design a precision nutritional intervention using a gut microbiome-based diet combined with medical treatment. After 2 months of a superfood dietary intervention, the patient showed signs of clinical improvement as evidenced by improved mobility and a change in the Hoehn and Yahr clinical severity scale from stages 3 to 2. In conclusion, it is possible to modulate the gut microbiome to reverse the established gut dysbiosis associated with the neurodegenerative process in PD, which can lead to clinical benefit by reducing functional disability.

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肠道微生物为基础的饮食干预帕金森病受试者:1例报告

一名54岁妇女在印度迈索尔JSS医院神经内科门诊部寻求帕金森病(PD)治疗。她在活动能力降低方面受到挑战，并寻求了几种治疗方案来控制她的PD症状，但没有成功的结果。在检查并确认诊断后，我们决定设计一种精确的营养干预，使用基于肠道微生物组的饮食结合药物治疗。经过2个月的超级食物饮食干预，患者表现出临床改善的迹象，包括活动能力的改善和Hoehn和Yahr临床严重程度量表从3级降至2级。总之，通过调节肠道微生物群来逆转PD患者与神经退行性过程相关的肠道生态失调是可能的，这可以通过减少功能残疾而带来临床益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nutrition, Pharmacology, Neurological Diseases Medicine-Pharmacology (medical)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The International Journal of Nutrition, Pharmacology, Neurological Diseases (IJNPND) is an international, open access, peer reviewed journal which covers all fields related to nutrition, pharmacology, neurological diseases. IJNPND was started by Dr. Mohamed Essa based on his personal interest in Science in 2009. This journal doesn’t link with any society or any association. The co-editor-in chiefs of IJNPND (Prof. Gilles J. Guillemin, Dr. Abdur Rahman and Prof. Ross grant) and editorial board members are well known figures in the fields of Nutrition, pharmacology, and neuroscience. First, the journal was started as two issues per year, then it was changed into 3 issues per year and since 2013, it publishes 4 issues per year till now. This shows the slow and steady growth of this journal. To support the reviewers and editorial board members, IJNPND offers awards to the people who does more reviews within one year. The International Journal of Nutrition, Pharmacology, Neurological Diseases (IJNPND) is published Quarterly. IJNPND has three main sections, such as nutrition, pharmacology, and neurological diseases. IJNPND publishes Research Papers, Review Articles, Commentaries, case reports, brief communications and Correspondence in all three sections. Reviews and Commentaries are normally commissioned by the journal, but consideration will be given to unsolicited contributions. International Journal of Nutrition, Pharmacology, Neurological Diseases is included in the UGC-India Approved list of journals.