The relationship of phosphodiesterase 5 inhibitors and male fertility: literature review

Abstract

The purpose of this literature review is to assess the role of phosphodiesterase 5 inhibitors not only in the treatment of erectile dysfunction, but also in the treatment of male infertility. Phosphodiesterase 5 inhibitors has a positive effect on the secretory function of Leydig and Sertoli cells, the biochemical environment in the vas deferens, the contractility of the testicular protein membrane and the secretory function of the prostate gland. In several studies, the effect of taking sildenafil positively affected the quantitative and qualitative motility of spermatozoa. In addition, some studies show that phosphodiesterase 5 inhibitors has a positive effect on the ability of spermatozoa to undergo capacitation. The “Vildegra” is the only sildenafil in a prolonged release form, with equal effectiveness, it has better tolerability compared to the original.