A Fungus for Our Time: Candida auris Emerges into the Anthropocene

IF 3.6 Q2 INFECTIOUS DISEASES
Juliet C. Stephenson, Dominic R. Garza, Tejas Bouklas
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引用次数: 1

Abstract

Abstract Purpose of Review Candida auris is a multi-drug-resistant pathogen with many phenotypic variations that contribute to its pathogenicity. This review aims to characterize its phenotypic heterogeneity while highlighting the variants that should be prioritized in future research to advance therapies against C. auris . Recent Findings As the Earth warms, fungi like Candida experience selective pressure to tolerate these higher temperatures and become the few fungal species capable of successfully colonizing the host. The most recent of these is C. auris , which has become an acute concern due to its rapid emergence, high mortality rate, and resistance to all known classes of antifungals. Summary Several studies have contributed rapidly to our general understanding of C. auris , but not enough has been experimentally verified on its morphological variation and its ability to maintain a successful commensal lifestyle on the human skin. Because of its distinct phenotypic variations compared to other fungal species, especially under the selective pressures of its host, C. auris presents a unique opportunity to identify unique targets and strategies to contribute to the antifungal pipeline and control emergent pathogens.
我们时代的真菌:金黄色念珠菌出现在人类世
摘要耳念珠菌是一种多重耐药病原菌,具有多种表型变异,导致其致病性。本综述旨在描述其表型异质性,同时强调在未来研究中应该优先考虑的变异,以推进针对金黄色葡萄球菌的治疗。随着地球变暖,像念珠菌这样的真菌经历了忍受高温的选择压力,成为少数能够成功殖民宿主的真菌物种。其中最近的是金黄色葡萄球菌,由于其出现迅速、死亡率高以及对所有已知种类的抗真菌药物具有耐药性,已成为一个严重问题。几项研究迅速使我们对金黄色葡萄球菌有了大致的了解,但对其形态变异及其在人类皮肤上维持成功共生生活方式的能力的实验验证还不够。由于其与其他真菌物种相比具有明显的表型变异,特别是在其宿主的选择压力下,金黄色葡萄球菌提供了一个独特的机会来确定独特的靶点和策略,以促进抗真菌管道和控制突发病原体。
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来源期刊
Current Tropical Medicine Reports
Current Tropical Medicine Reports Medicine-Infectious Diseases
CiteScore
9.30
自引率
1.90%
发文量
23
期刊介绍: Current Tropical Medicine Reports provides expert views on recent advances in the field of tropical medicine in a clear and readable form. This journal offers reviews by domestic and international contributors that highlight the most important, recent papers and findings related to this specific field. We accomplish this by appointing renowned leaders in major tropical medicine subject areas to select topics addressing virology, bacteriology, parasitology, entomology, immunology, cell and molecular biology, epidemiology, ecology, behavioral science and clinical medicine for review by experts who assess the latest developments and highlight significant papers published over the last few years on their topics. These review articles also stress recently published papers of importance in the references, which are accompanied by annotations explaining their importance. In addition to these Section Editors, our international Editorial Board ensures our journal upholds its standards.
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