Unusual Manifestation of Atrioventricular Dissociation in A 63 Year-Old Man and Clinical Insights

Abstract

Ivabradine is a specific funny current inhibitor, which blocks Hyperpolarization-activated Cyclic Nucleotide-gated cation channels intra-cellularly and results in delayed diastolic depolarization in a use-dependent manner. Prior-believed to be exclusively expressed within the sinoatrial node, funny channels were recently revealed to be also expressed in the atrioventricular node and throughout the myocardium. These invite a key clinical question as whether pharmacological effects of ivabradine may extend beyond its conventional clinical use.