Development of pyrazolo[1,5-a]pyrimidine derivatives: Synthesis, anticancer activity and docking study

Abstract

: It has been revealed that scaffolds made from pyrazolo[1,5-a]pyrimidines exhibit valuable biological activities, particularly anti-proliferative efficacy and blocking CDK activity. Therefore, new derivatives of pyrazolo[1,5-a]pyrimidines 5a-c were synthesized, and their chemical structures were validated using several spectral studies. These compounds were screened against MCF-7, HCT-116