Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2023-11-14 DOI:10.1016/j.jgr.2023.11.003

Young-Su Yi

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by hepatic fat accumulation, while nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD characterized by hepatic inflammation, fibrosis, and liver injury, resulting in liver cirrhosis and hepatocellular carcinoma (HCC). Given the evidence that ginseng and its major bioactive components, ginsenosides, have potent anti-adipogenic, anti-inflammatory, anti-oxidative, and anti-fibrogenic effects, the pharmacological effect of ginseng and ginsenosides on NAFLD and NASH is noteworthy. Furthermore, numerous studies have successfully demonstrated the protective effect of ginseng on these diseases, as well as the underlying mechanisms in animal disease models and cells, such as hepatocytes and macrophages. This review discusses recent studies that explore the pharmacological roles of ginseng and ginsenosides in NAFLD and NASH and highlights their potential as agents to prevent and treat NAFLD, NASH, and liver diseases caused by hepatic steatosis and inflammation.

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人参和人参皂苷在非酒精性脂肪肝和非酒精性脂肪性肝炎中的药理潜力

非酒精性脂肪性肝病（NAFLD）是一种以肝脏脂肪堆积为特征的慢性肝病，而非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病的一种晚期形式，其特征是肝脏炎症、纤维化和肝损伤，从而导致肝硬化和肝细胞癌（HCC）。有证据表明，人参及其主要生物活性成分人参皂甙具有强效的抗脂肪生成、抗炎、抗氧化和抗纤维化作用，因此人参和人参皂甙对非酒精性脂肪肝和非酒精性脂肪肝的药理作用值得关注。此外，许多研究已成功证明了人参对这些疾病的保护作用，以及在动物疾病模型和细胞（如肝细胞和巨噬细胞）中的潜在机制。本综述讨论了探讨人参和人参皂苷在非酒精性脂肪肝和非酒精性脂肪性肝病中的药理作用的最新研究，并强调了它们作为预防和治疗非酒精性脂肪肝、非酒精性脂肪性肝病以及由肝脏脂肪变性和炎症引起的肝病的药物的潜力。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.