HDAC inhibitors: A novel approach to hyperglycaemia management and treatment

M. Suchitra , Kusuma Praveen Kumar , Manjunath.S. Katagi , Garla Venkateswarlu , P.Sree Mahalakshmi
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引用次数: 0

Abstract

The field of genomics plays a prominent role in treatment of numerous chronic diseases. Diabetes is a persistent metabolic disorder. Current studies and reports have emphasised the importance of several epigenetic markers in the therapy of type 2 diabetes. Histone Deacetylases(HDAC) enzyme regulate the structure of chromatin and the transcription of genes in the nucleus that produce proteins that regulate metabolic processes in the body. It influences gene expression primarily by removing an acetyl group from its precursor protein, and it regulates acetylation metabolic enzymes in mitochondria and cytoplasm. The balance between histone acetylation and deacetylation is an epigenetic layer that modulates gene expression. Gene transcription is associated with histone acetylation induced by histone acetyl transferases, whereas histone hypoacetylation influenced by histone deacetylase activity is related with gene silencing. This review focuses on the role of histone deacetylase inhibitors as a newly discovered treatment for diabetes and its impediment, defining their use in preventing insulin resistance, cell death, and cytokine-mediated attack on pancreatic cells.

HDAC抑制剂:高血糖管理和治疗的新途径
基因组学领域在许多慢性疾病的治疗中起着突出的作用。糖尿病是一种持续性代谢紊乱。目前的研究和报道强调了几种表观遗传标记在2型糖尿病治疗中的重要性。组蛋白去乙酰化酶(HDAC)调节染色质的结构和细胞核中基因的转录,这些基因产生调节体内代谢过程的蛋白质。它主要通过从前体蛋白中去除乙酰基来影响基因表达,并调节线粒体和细胞质中的乙酰化代谢酶。组蛋白乙酰化和去乙酰化之间的平衡是调节基因表达的表观遗传层。基因转录与组蛋白乙酰转移酶诱导的组蛋白乙酰化有关,而受组蛋白去乙酰化酶活性影响的组蛋白低乙酰化与基因沉默有关。本文综述了组蛋白去乙酰化酶抑制剂作为一种新发现的治疗糖尿病及其障碍的药物的作用,定义了它们在预防胰岛素抵抗、细胞死亡和细胞因子介导的胰腺细胞攻击中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Health sciences review (Oxford, England)
Health sciences review (Oxford, England) Medicine and Dentistry (General)
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75 days
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