Huibin Yang, Haibo Yu, Yunbo Cong, Xuegeng Shi, Zhinan Hu, Junfeng Wang, Yuquan Song, Bin Li
{"title":"Anthranilic diamide compounds: Discovery of tetrachlorantraniliprole","authors":"Huibin Yang, Haibo Yu, Yunbo Cong, Xuegeng Shi, Zhinan Hu, Junfeng Wang, Yuquan Song, Bin Li","doi":"10.1016/j.aac.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><p>Given the development of insects’ resistance and deteriorative ecological environment, the discovery of insecticides with a new mode of action has been proven to be an important tool for comprehensive pest management. Herein, a novel anthranilic diamides containing 3,5-dichloropyridylpyrazole group were designed and synthesized. Their insecticidal potency was assayed against beet armyworm (<em>Spodoptera exigua</em>). Moreover, the structure-activity relationship of these new compounds was also discussed. Of them, compound <strong>15g</strong> exhibited potential insecticidal activity. Because of the excellent efficacy against a series of Lepidoptera and low toxicity to mammals, compound <strong>15g</strong>, namely tetrachlorantraniliprole, has been developed and launched into the market as an insecticide.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"2 4","pages":"Pages 371-375"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237123000801/pdfft?md5=6d849025784eb430c224e9882a18bf62&pid=1-s2.0-S2773237123000801-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Agrochem","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773237123000801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Given the development of insects’ resistance and deteriorative ecological environment, the discovery of insecticides with a new mode of action has been proven to be an important tool for comprehensive pest management. Herein, a novel anthranilic diamides containing 3,5-dichloropyridylpyrazole group were designed and synthesized. Their insecticidal potency was assayed against beet armyworm (Spodoptera exigua). Moreover, the structure-activity relationship of these new compounds was also discussed. Of them, compound 15g exhibited potential insecticidal activity. Because of the excellent efficacy against a series of Lepidoptera and low toxicity to mammals, compound 15g, namely tetrachlorantraniliprole, has been developed and launched into the market as an insecticide.
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