Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome

Abstract

• The m7G-lncRNAs were identified through whole transcriptome-seq of PD and RIP validation. • The anti-VM effect of PD on NSCLC was investigated both in vivo and in vitro. • The synergistic effect was found in combinational use of PD and eIF4E inhibitor on NSCLC via destabilization of EGFR.