Secretory carcinoma of breast: No more a juvenile tumor

Abstract

: Secretory breast carcinoma (SBC) is one of the rare breast neoplasm with an incidence rate of < 0.15% of all breast cancers. Previously it was described as juvenile breast carcinoma. Young children and adolescent girls are most commonly affected. It is characterized by balanced translocation t (12;15), ETV6-NTRK3 gene fusion. : A 45 -year-old female presented with palpable lump in left breast. FNAC was suggestive of mucinous carcinoma. The diagnosis of SBC was made through histopathology and Immunohistochemistry : Recent study report suggested that the disease may also occur at a later age group in contrast to the conventional thought of onset at juvenile age group. Long-term survival is good for these cases. In radiological studies of breast imaging it mimics a benign tumour Immuno-histochemistry and cytogenetic are of the tumour are the ancillary investigations for confirmation of diagnosis. : Although rare diagnosis of SBC can be confirmed by histopathological studies and IHC. It is slowly progressive but has a good prognosis.