In silico evaluation of isoflavones for its galactagogue activity in promoting lactation

Abstract

Breastfeeding is crucial for the health of both mothers and infants, providing both short-term and long-term benefits. Breast milk contains all the necessary nutrients for both the mother and child. Unfortunately, many women are experiencing a low milk supply, resulting in infants not receiving sufficient immune support. To increase milk production, there are various herbal and pharmaceutical galactagogues available. Plants in the Caryophyllaceae family contain phytoestrogen, a compound that helps stimulate milk production. Isoflavone is one type of phytoestrogens. Isoflavones have many properties like bactericidal, fungicidal and anti-ringworm and are used to treat breast and prostate cancer and bone-related diseases. Spergula arvensis L., a member of the Caryophyllaceae family, is rich in isoflavones. Nine specific compounds were chosen due to their connection to mammary gland function. A preliminary in silico study was conducted to examine the interaction between isoflavones and prolactin receptors through molecular docking. The compound quercetin, an isoflavone, showed a better binding affinity to the receptor.