To Study the Clinical and Etiological Profile of Patients with Hepatic Encephalopathy

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Abstract

Hepatic encephalopathy (HE) is a term used to describe a reversible syndrome of impaired brain function involvinga complex spectrum of nonspecific neurological and psychiatric manifestations occurring in patients of severeacute or chronic liver insufficiency. Hepatic encephalopathy (HE) is one of the most devastating complication ofcirrhosis having high morbidity and mortality. There is very limited data regarding the incidence and risk factorsof hepatic encephalopathy so this study is to find the clinical and etiological profile of hepatic encephalopathy.Methodology: The study was conducted in patients visited in OPD/IPD of medicine department, SGRDIMSR,Amritsar (Punjab) in the time period from 1 April 2021 to 31 July 2022. A total of 150 patients were taken up forthis study. All the diagnosed patients of liver cirrhosis of any etiology (Recently detected or old patients) wereincluded in the study.FindingsIn this study most of patients were males (81%) in the age group of 31 to 60 yrs (65%). Most common etiologyfound to be alcoholic (53%) with presenting symptoms of altered talks(51%).Conclusion: Education of the society about the precipitating factors can lead to early detection of hepaticencephalopathy and thus decrease the morbidity and mortality related to it. So there is need for Screeningprograms and education.
目的:探讨肝性脑病的临床及病因特点
肝性脑病(HE)是一个术语,用于描述一种可逆的脑功能受损综合征,涉及复杂的非特异性神经和精神表现,发生在严重急性或慢性肝功能不全患者中。肝性脑病(HE)是肝硬化最具破坏性的并发症之一,具有很高的发病率和死亡率。关于肝性脑病的发病率和危险因素的资料非常有限,因此本研究旨在了解肝性脑病的临床和病因学概况。方法:研究对象为2021年4月1日至2022年7月31日在阿姆利则(旁遮普省)SGRDIMSR内科门诊/IPD就诊的患者。这项研究共纳入了150名患者。所有诊断为肝硬化的任何病因的患者(新近发现或老年患者)都被纳入研究。在本研究中,大多数患者为男性(81%),年龄在31 - 60岁(65%)。最常见的病因是酒精中毒(53%),伴有说话改变的症状(51%)。结论:社会对肝性脑病的发病因素进行教育,可以早期发现肝性脑病,从而降低肝性脑病的发病率和死亡率。所以我们需要筛查项目和教育。
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