{"title":"Identification and Expression Analysis of IL-10 Family in Spotted Sea Bass (Lateolabrax maculatus)","authors":"Yuxi Chen, Qian Gao, Zhitao Qi, Chong Xu, Tingshuang Pan, Dong Liu, Qigen Liu","doi":"10.1155/2023/6647666","DOIUrl":null,"url":null,"abstract":"Interleukin (IL)-10 family members play important roles in regulating the immune responses during host defense. In the present study, four IL-10 family members (IL-10, IL-20L, IL-22, and IL-26) were identified from spotted sea bass (Lateolabrax maculatus) and their expression patterns were investigated following Edwardsiella tarda and lipopolysaccharide (LPS) challenge. The four ILs of spotted sea bass shared conserved features of IL-10 family and were well clustered with the IL-10 family of fish, respectively. The expressions of these four ILs in normal tissues were different, but all were highly expressed in gills, indicating their roles in mucosal immunity. After E. tarda and LPS challenge, the four ILs were upregulated in several immune-related tissues (gills, head kidney, intestine, and spleen). These results indicated that these four ILs involved in the antibacterial immune responses of spotted sea bass, providing basis for understanding the function and networks of IL-10 family members in fish.","PeriodicalId":8104,"journal":{"name":"Aquaculture Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aquaculture Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/6647666","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FISHERIES","Score":null,"Total":0}
引用次数: 0
Abstract
Interleukin (IL)-10 family members play important roles in regulating the immune responses during host defense. In the present study, four IL-10 family members (IL-10, IL-20L, IL-22, and IL-26) were identified from spotted sea bass (Lateolabrax maculatus) and their expression patterns were investigated following Edwardsiella tarda and lipopolysaccharide (LPS) challenge. The four ILs of spotted sea bass shared conserved features of IL-10 family and were well clustered with the IL-10 family of fish, respectively. The expressions of these four ILs in normal tissues were different, but all were highly expressed in gills, indicating their roles in mucosal immunity. After E. tarda and LPS challenge, the four ILs were upregulated in several immune-related tissues (gills, head kidney, intestine, and spleen). These results indicated that these four ILs involved in the antibacterial immune responses of spotted sea bass, providing basis for understanding the function and networks of IL-10 family members in fish.
期刊介绍:
International in perspective, Aquaculture Research is published 12 times a year and specifically addresses research and reference needs of all working and studying within the many varied areas of aquaculture. The Journal regularly publishes papers on applied or scientific research relevant to freshwater, brackish, and marine aquaculture. It covers all aquatic organisms, floristic and faunistic, related directly or indirectly to human consumption. The journal also includes review articles, short communications and technical papers. Young scientists are particularly encouraged to submit short communications based on their own research.