Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis

Q4 Medicine

Voprosy Sovremennoi Pediatrii - Current Pediatrics Pub Date : 2023-11-05 DOI:10.15690/vsp.v22i5.2640

Nikolay N. Murashkin, Alexander I. Materikin, Roman V. Epishev, Maria A. Leonova, Leonid A. Opryatin, Roman A. Ivanov, Alena A. Savelova

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Abstract

Background. Excessive colonization of the skin by various bacteria and fungi can be noted in patients with atopic dermatitis (AD), and the prevalence of secondary infection complications 30–48%. Several studies have shown that Staphylococcus aureus colonization is 60–100% in patients with AD compared to 5–30% in healthy persons from the control group. Moreover, the incidence of methicillinresistant Staphylococcus aureus (MRSA) isolates is up to 10–30% in skin cultures at AD, according to experts. Therapy of AD complicated by secondary infection is one of the crucial challenges of modern dermatology. Mupirocin can be considered as one of the most effective topical antibiotic among others used for etiotropic therapy of infectious complications in AD patients, and it has been confirmed by numerous clinical studies. Conclusion. Staphylococcus aureus is the most common trigger of AD aggravation. MRSA in AD complicated by secondary infection is difficult to manage as it becomes resistant to many types of antibiotics; however, it shows persistent sensitivity to mupirocin. Mupirocin-based (2%) external agent is the most effective, safe, and preferred therapy variant for AD complicated by secondary infection in pediatrics.

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特应性皮炎患儿金黄色葡萄球菌抗生素敏感性特点

背景。特应性皮炎(AD)患者可注意到各种细菌和真菌在皮肤上的过度定植，继发感染并发症的发生率为30-48%。几项研究表明，金黄色葡萄球菌在AD患者中的定植率为60-100%，而对照组健康人群的定植率为5-30%。此外，据专家称，在AD患者的皮肤培养中，耐甲氧西林金黄色葡萄球菌(MRSA)分离株的发病率高达10-30%。阿尔茨海默病并发继发感染的治疗是现代皮肤病学的关键挑战之一。莫匹罗星是AD患者感染性并发症致病因治疗中最有效的外用抗生素之一，已被大量临床研究证实。结论。金黄色葡萄球菌是最常见的阿尔茨海默病加重诱因。由于耐甲氧西林金黄色葡萄球菌对许多类型的抗生素具有耐药性，因此在AD中并发继发感染是难以控制的;然而，它对莫匹罗星表现出持久的敏感性。以莫匹罗星为基础(2%)的外用药物是儿科AD并发继发感染最有效、最安全、最优选的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Voprosy Sovremennoi Pediatrii - Current Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main purpose of the academic journal "Current Pediatrics" is to cover the issues related to health, emotional state, and social adaptation of children. In the journal we publish the most pressing issues of research and applied problems (such as social paediatrics; clinical findings, anamnesis, and diagnosis of paediatric diseases; prevention and rehabilitation; supply of healthy and sick child), reviews on the current state of medical science and management of health care in Russia. Along with the concern for providing a high level of basic research publications, the journal, being a mass media tool, tends to meet the interests and requirements of practitioners from different regions and bring up vital and urgent questions. To accomplish this purpose the journal includes the materials of practical interest presented in the following sections: "Exchange of experience", "Doctor''s aid", "Continuous professional education", "Expert Opinion". The journal presents actual official information from the Union of Paediatricians of Russia and publishes materials on the history of medical science, congresses, seminars, conferences, both in our country and abroad.