Skin Microbiome Composition and Key Factors of its Barrier Function

Q4 Medicine
Nikolay N. Murashkin, Ekaterina S. Pavlova, Roman V. Epishev, Alexander I. Materikin, Roman A. Ivanov, Alena A. Savelova, Dmitriy V. Fedorov, Maria A. Leonova
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引用次数: 0

Abstract

The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection. The microbiome plays a crucial role in maintaining normal skin functioning: control of pathogenic diversity of microorganisms, stimulate immune cells, and modulate chronic dermatoses development. There are various mechanisms for restoring skin barrier function. They are associated with the microorganisms’ activity. Thus, skin restoration is an important task included in the general concept of atopic dermatitis management. One of such methods is the skin surface colonization with commensals, so significant role is assigned to the new dermatological drugs. The normalization of the microbiome in affected skin areas with cosmetic care products can significantly affect the result of skin barrier restoration.
皮肤微生物组成及其屏障功能的关键因素
皮肤是人体最大的器官,它在内部和外部环境之间形成保护屏障。皮肤屏障损伤可导致体内平衡失衡、炎症或细菌感染。微生物组在维持正常皮肤功能方面起着至关重要的作用:控制微生物的致病多样性,刺激免疫细胞,调节慢性皮肤病的发展。修复皮肤屏障功能有多种机制。它们与微生物的活动有关。因此,皮肤修复是包括在特应性皮炎管理的一般概念的重要任务。其中一种方法是用共生菌在皮肤表面定植,因此新的皮肤病药物具有重要的作用。用化妆品护理产品使受影响皮肤区域的微生物组正常化可以显著影响皮肤屏障修复的结果。
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来源期刊
Voprosy Sovremennoi Pediatrii - Current Pediatrics
Voprosy Sovremennoi Pediatrii - Current Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.70
自引率
0.00%
发文量
48
审稿时长
8 weeks
期刊介绍: The main purpose of the academic journal "Current Pediatrics" is to cover the issues related to health, emotional state, and social adaptation of children. In the journal we publish the most pressing issues of research and applied problems (such as social paediatrics; clinical findings, anamnesis, and diagnosis of paediatric diseases; prevention and rehabilitation; supply of healthy and sick child), reviews on the current state of medical science and management of health care in Russia. Along with the concern for providing a high level of basic research publications, the journal, being a mass media tool, tends to meet the interests and requirements of practitioners from different regions and bring up vital and urgent questions. To accomplish this purpose the journal includes the materials of practical interest presented in the following sections: "Exchange of experience", "Doctor''s aid", "Continuous professional education", "Expert Opinion". The journal presents actual official information from the Union of Paediatricians of Russia and publishes materials on the history of medical science, congresses, seminars, conferences, both in our country and abroad.
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