Genetic polymorphism of CTLA4 with functional thyroid tests in hypothyroid disease patients

Abstract

Objective: To recognize the role of Cytotoxic T-Lymphocyte Antigen 4 CTLA4 gene polymorphism (rs231775A/G) in Hashimoto's thyroiditis (HT) patients and a study its correlation with other clinical data.Design and MethodsCase-control research was conducted on 200 females, with 100 patients with Hashimoto's thyroiditis aged 18-68 years and 100 age and gender-matched healthy volunteers. Patients were drawn from Al-Sadder Medical City in Al-Najaf Governorate. All participants underwent to medical examinations to ensure they were suffering from Hashimoto's thyroiditis. The Real-time-PCR method was used to analyze the genotyping of the CTLA4 gene, and the levels of T3, T4, TSH, Anti-TPO, and Anti-TG were assessed using an ELISA kit in all study groups