Development of Anti-aging Cosmetics Using Chitosan/ γ-Cyclodextrin/Fucoidan Nanoparticles (Nanogel) Based on the Drug Delivery System

Da-In Choi, Min-Kyeong Ju, Su-Mi Park, Sook-Young Lee
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Abstract

Purpose: This study aimed to develop MARINAVI-FD, a cosmetic material containing γ-cyclodextrin/chitosan/fucoidan nanoparticles, i.e., CH-γ-CD-Fu (Nanogel) based on the DDS system, and anti-aging cosmetics that have proven antioxidant and moisturizing effects.Methods: CH-γ-CD-Fu (nanogel) was identified through electron microscope (scanning electron microscope) analysis and nanoparticle size analysis (dynamic light scattering). Radical scavenging DPPH and ABTS assays were performed. Skin keratinocytes (HaCat cells) was assessed by the MTT assay, and the moisturizing effect was evaluated through enzyme-linked immunosorbent assay. Temperature and storage conditions were checked for the stability of the formulation. In the human body application test, Moisture Meter D Compact device was used.Results: The CH-γ-CD-Fu (Nanogel) has confirmed particle size of approximately 500 nm. In the DPPH and ABTS assays, compared with Fu (foucoidan), the CH-γ-CD-Fu (nanogel) showed higher scavenging ability at treatment concentration of 15.625–500 μg/mL. CH-γ-CD-Fu (Nanogel) showed a survival rate of >80% in skin keratinocytes (HaCat cells) up to a concentration of 5,000 μg/mL. In the measurement of hyaluronic acid production, CH-γ-CD-Fu (Nanogel) showed better production at 194.87 ng/mL than at 121.47 ng/mL at a concentration of 200 μg/mL in the control group. The stability of skin and cream formulations of anti-aging cosmetics containing MARINAVI-FD was confirmed. The moisturizing effect was observed 2.5 mm depth of skin human application.Conclusion: In this study, CH-γ-CD-Fu (nanogel) was used to materialize into anti-aging cosmetics.
基于给药系统的壳聚糖/ γ-环糊精/岩藻聚糖纳米颗粒(纳米凝胶)抗衰老化妆品的研制
目的:研制基于DDS体系的含有γ-环糊精/壳聚糖/褐藻聚糖纳米粒子(CH-γ-CD-Fu (Nanogel))的化妆品材料marinai - fd,以及具有抗氧化和保湿作用的抗衰老化妆品。方法:通过电子显微镜(扫描电镜)分析和纳米粒度分析(动态光散射)对CH-γ-CD-Fu(纳米凝胶)进行鉴定。进行自由基清除DPPH和ABTS检测。MTT法评估皮肤角质形成细胞(HaCat细胞),酶联免疫吸附法评估保湿效果。考察了温度和贮存条件对制剂稳定性的影响。在人体应用试验中,采用湿度计D紧凑型装置。结果:CH-γ-CD-Fu(纳米凝胶)的粒径约为500 nm。在DPPH和ABTS实验中,CH-γ-CD-Fu(纳米凝胶)在处理浓度为15.625 ~ 500 μg/mL时表现出较强的清除能力。在5000 μg/mL浓度下,CH-γ-CD-Fu (Nanogel)在皮肤角质形成细胞(HaCat细胞)中的存活率为80%。在透明质酸产量测定中,CH-γ-CD-Fu (Nanogel)在浓度为200 μg/mL时,在194.87 ng/mL时的产量优于121.47 ng/mL。证实了含MARINAVI-FD的抗衰老化妆品护肤霜配方的稳定性。在人体皮肤2.5 mm深度处观察保湿效果。结论:CH-γ-CD-Fu(纳米凝胶)可制备抗衰老化妆品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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