Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report

IF 1 Q4 GASTROENTEROLOGY & HEPATOLOGY

GE Portuguese Journal of Gastroenterology Pub Date : 2023-09-01 DOI:10.1159/000533499

Raquel R. Mendes, Pedro C. Figueiredo, Isabel Andrade

引用次数: 0

Abstract

Introduction: Obinutuzumab is a type II anti-CD20 monoclonal antibody associated with a higher rate of toxicity when compared to rituximab. Gastrointestinal side-effects have been reported but data is still sparse. Case Presentation: A 47-year-old female with medical history of stage IV follicular non-Hodgkin lymphoma under chemotherapy presented with chronic bloody diarrhea and iron deficiency anemia. Endoscopic and histologic features resembled inflammatory bowel disease (IBD), imposing a thorough differential diagnosis. The diagnosis of obinutuzumab-induced pancolitis was made and the drug was suspended with subsequent clinical improvement. Conclusion: This is the first case report of obinutuzumab-induced pancolitis. The challenging differential diagnosis of IBD required a multidisciplinary approach with subsequent outcome and management implications.

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obinutuzumab诱导的炎症性肠病样全结肠炎:首例报告

& lt; b> & lt; i>简介:& lt; / i> & lt; / b>与利妥昔单抗相比，Obinutuzumab是一种II型抗cd20单克隆抗体，具有更高的毒性。胃肠道副作用已经有报道，但数据仍然很少。& lt; b> & lt; i>案例表示:& lt; / i> & lt; / b>47岁女性，有IV期滤泡性非霍奇金淋巴瘤病史，化疗后出现慢性血性腹泻和缺铁性贫血。内镜和组织学特征类似炎症性肠病(IBD)，强制彻底鉴别诊断。诊断为obinutuzumab诱导的全结肠炎，停药，随后临床改善。& lt; b> & lt; i>结论:& lt; / i> & lt; / b>这是第一例报告的obinutuzumab诱导的全结肠炎。IBD具有挑战性的鉴别诊断需要多学科的方法，并具有后续的结果和管理意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GE Portuguese Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

21 weeks

期刊介绍： The ''GE Portuguese Journal of Gastroenterology'' (formerly Jornal Português de Gastrenterologia), founded in 1994, is the official publication of Sociedade Portuguesa de Gastrenterologia (Portuguese Society of Gastroenterology), Sociedade Portuguesa de Endoscopia Digestiva (Portuguese Society of Digestive Endoscopy) and Associação Portuguesa para o Estudo do Fígado (Portuguese Association for the Study of the Liver). The journal publishes clinical and basic research articles on Gastroenterology, Digestive Endoscopy, Hepatology and related topics. Review articles, clinical case studies, images, letters to the editor and other articles such as recommendations or papers on gastroenterology clinical practice are also considered. Only articles written in English are accepted.