Bacterial Predominance and Antimicrobial Susceptibility Patterns of Blood Culture at a Tertiary Care Hospital, Bangladesh

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2023-10-04 DOI:10.3329/jninb.v9i1.65403

Tarana Jahan, Md Abdullah Yusuf, Khandaker Md Tasnim Sajid, Sharmeen Sultana, Md Mostaqimur Rahman, Afroza Sultana

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Abstract

Background: The problem of widespread resistant bacteria has become a major threat to reduce the effectiveness of antibiotics worldwide. Objective: The aim of this study was to identify the bacterial pathogens from bold culture and determine their antibiotic susceptibility pattern. Methodology: This cross-sectional study was conducted in the department of Microbiology at Monno Medical College, Manikganj, Bangladesh during the period from January 2019 to December 2019 for duration of one year. Blood was collected according to blood collection guidelines and inoculated into BacT/ALERT FA plus and BacT/ALERT PF plus aerobic blood culture bottles respectively. After collection these bottles were immediately incubated in BacT/ALERT 3D (manufactured by bioMerieoux, France) a fully automated blood culture system. Antimicrobial susceptibility test was done for all isolated bacteria by disc diffusion method. Results: A total number of 180 patients were recruited, among them 12 (7%) yielded growth of different bacteria. The most frequently isolated bacteria were Streptococcus Spp 5(42%) followed by Staphylococcus aureus and Escherichia coli which were 4(33%) and 3(25%) respectively. Escherichia Coli which showed highly sensitive to Imipenum, Amikacin, Linezolid, Gentamicin (N=3, 100%). Conclusion: There were a high percentage of bacteria isolated from blood culture and resistant to several antibiotics. For the selection of appropriate antibiotic therapy in bacterial infections the antibiotic susceptibility testing is mandatory. Journal of National Institute of Neurosciences Bangladesh, January 2023;9(1):48-53

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孟加拉国一家三级护理医院血液培养的细菌优势和抗菌药物敏感性模式

背景:广泛存在的耐药菌问题已成为降低抗生素有效性的主要威胁。目的:从大胆培养中鉴定病原菌并确定其药敏模式。方法:本横断面研究于2019年1月至2019年12月在孟加拉国Manikganj Monno医学院微生物学系进行，为期一年。按采血指南采血，分别接种于BacT/ALERT FA +和BacT/ALERT PF +有氧血培养瓶中。收集后，这些瓶子立即在BacT/ALERT 3D(法国bioMerieoux公司制造)全自动血液培养系统中孵育。所有分离菌均采用纸片扩散法进行药敏试验。结果:共纳入180例患者，其中12例(7%)产生不同细菌。检出最多的细菌是5型链球菌(42%)，其次是金黄色葡萄球菌(4株)和大肠杆菌(3株)，分别为33%和25%。大肠杆菌对亚胺培南、阿米卡星、利奈唑胺、庆大霉素高度敏感(N= 3,100%)。结论:血培养分离出的细菌对多种抗生素耐药的比例较高。为了在细菌感染中选择合适的抗生素治疗，抗生素敏感性试验是强制性的。孟加拉国国家神经科学研究所杂志，2023年1月;9(1):48-53

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Journal of National Institute of Neurosciences Bangladesh

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