The catalyst-free polytransesterification for obtaining linear PGS optimized with use of 22 factorial design

IF 0.5 4区工程技术 Q4 ENGINEERING, CHEMICAL

Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa Pub Date : 2023-11-06 DOI:10.24425/cpe.2021.137338

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引用次数: 2

Abstract

Poly(glycerol sebacate) (PGS) is a polyester that is particularly useful for tissue engineering applications. Many researchers have focused on the application and characterization of materials made from PGS. Synthesis is often superﬁcially described, and the prepolymer is not characterized before crosslinking. Considering the diﬀerent functionality of each monomer (glycerine – 3, sebacic acid – 2), materials with a branched structure can be obtained before the crosslinking process. Branched structures are not desirable for elastomers. In this work, method to obtain linear PGS resins is presented. Moreover, synthesis was optimized with the use of the Design of Experiments method for minimizing the degree of branching and maximizing the molecular weight. The process was described via mathematical models, which allows to the association of process parameters with product properties. In this work ca. 1kDa and less than 10% branched PGS resin was produced. This resin could be used to make very ﬂexible elastomers because branching is minimized.

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采用22因子设计优化无催化剂多酯交换法制备线性PGS

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来源期刊

Chemical and Process Engineering-Inzynieria Chemiczna I Procesowa 工程技术-工程：化工

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The content, aim and scope of the proposals should comply with the main subject of the journal, i.e. they should deal with mathematical modelling and/or experimental investigations on momentum, heat and mass transfer, unit processes and operations, integrated processes, biochemical engineering, statics and kinetics of chemical reactions. The experiments and modelling may cover different scales and processes ranging from the molecular phenomena up to production systems. The journal language is grammatically correct British English. Chemical and Process Engineering publishes: i) full text research articles, ii) invited reviews, iii) letters to the editor and iv) short communications, aiming at important new results and/or applications. Each of the publication form is peer-reviewed by at least two independent referees.