Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2023-10-01 DOI:10.1016/j.chmed.2023.09.003

Hanyu Zhang , Bowen Jin , Xinyu You , Pengrong Yi , Hong Guo , Lin Niu , Qingsheng Yin , Jiangwei Shi , Yanjun Zhang , Pengwei Zhuang

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Abstract

Ischemic stroke (IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator (r-tPA). Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine (TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates inflammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs.

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中药防治缺血性脑卒中的药效学优势及特点

缺血性脑卒中是一种发病率高、死亡率高、致残率高的严重脑血管疾病。IS的一线治疗是使用重组组织型纤溶酶原激活剂(r-tPA)。遗憾的是，由于狭窄的治疗窗口和相关的出血风险，许多患者遇到治疗延误。中医药在防治IS方面已显示出明显的优势。中药促进脑微循环，缓解神经系统疾病，调节能量代谢，减轻炎症，减少氧化应激损伤，抑制细胞凋亡，从而减轻脑损伤，防止IS复发。本文从中医角度综述IS的病因、病机、治疗策略及其与现代生物学的关系，阐述中医药治疗IS的优势，并进一步综述中医药在IS急性期、恢复期及脑卒中后并发症的药效学特点及优势。为中医药在IS防治中的临床应用以及新药的开发提供了有价值的见解和参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.