Preparation, Characterization and Stability Study of Eugenol-Loaded Eudragit RS100 Nanocapsules for Dental Sensitivity Reduction

IF 1 4区生物学 Q3 BIOLOGY

Brazilian Archives of Biology and Technology Pub Date : 2023-01-01 DOI:10.1590/1678-4324-ssbfar-2023230300

Ana Paula Vilela, Leandro Ferreira, Patrícia Bubna Biscaia, Karine Letícia da Silva, Flávio Luís Beltrame, Guilherme dos Anjos Camargo, Marcia Rezende, Jessica Mendes Nadal, Andressa Novatski, Jane Manfron, Alessandro Dourado Loguercio, Paulo Vitor Farago

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Abstract

HIGHLIGHTS Eugenol-loaded Eudragit RS100 nanocapsules were suitably obtained and characterized. A simple and fast UPLC/MS-MS method for determining eugenol in Eudragit RS100 nanocapsules was developed and validated. Eugenol-loaded Eudragit RS100 nanocapsules showed physical stability after 60 days of preparation. Eugenol-loaded Eudragit RS100 nanocapsules may be further used for reducing dental sensitivity.

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载丁香酚金楝草RS100纳米胶囊的制备、表征及稳定性研究

制备了载丁香酚的乌龙茶RS100纳米胶囊并对其进行了表征。建立了一种快速、高效液相色谱/质谱联用测定乌龙茶RS100纳米胶囊中丁香酚含量的方法。制备60天后，载丁香酚的香木犀草RS100纳米胶囊具有良好的物理稳定性。载丁香酚的丁香精油RS100纳米胶囊可进一步用于降低牙齿敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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