Ripened and Revamped-Adult T Cell Leukaemia/ Lymphoma

Abstract

Adult T cell leukaemia/ lymphoma is an aggressive T cell malignant disorder comprised of significantly pleomorphic, miniature to intermediate, mature CD4+ T cells. Factors such as demographic distribution within HTLV1 endemic zones, hypercalcemia, cutaneous lesions and a leukemic phase contribute to disease emergence. Adult T cell leukaemia/ lymphoma incriminates peripheral blood, lymph nodes, spleen, cutaneous surfaces, pulmonary or hepatic parenchyma, gastrointestinal tract and central nervous system. Bone marrow may demonstrate diffuse, interstitial or sinusoidal pattern of neoplastic occurrence. Generally, tumour cells are permeated with basophilic cytoplasm, absent intracytoplasmic granules, irregular or poly-lobulated nuclei with homogeneous, condensed nuclear chromatin and miniature nucleoli.