A Systemic Review on Photodynamic Therapy: Emerging Technology with Healing Process

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2023-10-05 DOI:10.2174/0115733947263042230920040145

Prachi varshney, Yogesh Kumar, Devdhar Yadav, Amit Singh, Naga Rani Kagithala, Pramod Kumar Sharma, Omji Porwal, Neeraj Kumar Fuloria, Pradeep Kumar Sharma, Ashok Kumar Gupta, GSN Koteswara Rao

{"title":"A Systemic Review on Photodynamic Therapy: Emerging Technology with Healing Process","authors":"Prachi varshney, Yogesh Kumar, Devdhar Yadav, Amit Singh, Naga Rani Kagithala, Pramod Kumar Sharma, Omji Porwal, Neeraj Kumar Fuloria, Pradeep Kumar Sharma, Ashok Kumar Gupta, GSN Koteswara Rao","doi":"10.2174/0115733947263042230920040145","DOIUrl":null,"url":null,"abstract":"Abstract: Photodynamic therapy (PDT) is a non-invasive treatment of cancer patients who take a photosensitizer and expose their tumours to light after administering it topically or intravenously. Understanding apoptosis under oxidative conditions makes PDT a more effective treatment. Tissue oxygen, tumour-selective photosensitizer dyes, and customised lighting are needed to create fatal reactive oxygen species (ROS) in cancer. PDT has decreased morbidity and improved survival and status of life when used in combination with other treatments, especially in early-stage malignant tumours. Using interstitial light delivery, PDT can cure large, hidden tumours that would otherwise necessitate extensive surgery. This overview describes the foundational historical work that has shaped the technique since the early 1900s. PDT's efficacy is also increased by innovative photosensitizers and tweaks that increase tumour selectivity. Adverse effects and treatment during therapy, as well as innovative PDT-based applications, are explored in this review. Finally, PDT research gaps and clinical trials have been identified as potential issues.","PeriodicalId":43754,"journal":{"name":"Current Cancer Therapy Reviews","volume":"28 1","pages":"0"},"PeriodicalIF":0.4000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Cancer Therapy Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115733947263042230920040145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract: Photodynamic therapy (PDT) is a non-invasive treatment of cancer patients who take a photosensitizer and expose their tumours to light after administering it topically or intravenously. Understanding apoptosis under oxidative conditions makes PDT a more effective treatment. Tissue oxygen, tumour-selective photosensitizer dyes, and customised lighting are needed to create fatal reactive oxygen species (ROS) in cancer. PDT has decreased morbidity and improved survival and status of life when used in combination with other treatments, especially in early-stage malignant tumours. Using interstitial light delivery, PDT can cure large, hidden tumours that would otherwise necessitate extensive surgery. This overview describes the foundational historical work that has shaped the technique since the early 1900s. PDT's efficacy is also increased by innovative photosensitizers and tweaks that increase tumour selectivity. Adverse effects and treatment during therapy, as well as innovative PDT-based applications, are explored in this review. Finally, PDT research gaps and clinical trials have been identified as potential issues.

查看原文本刊更多论文

光动力疗法:与愈合过程相关的新兴技术综述

摘要:光动力疗法(PDT)是一种非侵入性治疗癌症患者服用光敏剂并在局部或静脉注射后将肿瘤暴露在光线下的治疗方法。了解氧化条件下的细胞凋亡使PDT成为一种更有效的治疗方法。组织氧、肿瘤选择性光敏剂染料和定制照明需要在癌症中产生致命的活性氧(ROS)。PDT在与其他治疗联合使用时，特别是在早期恶性肿瘤中，降低了发病率，改善了生存率和生活状态。利用间质性光传输，PDT可以治愈大的、隐藏的肿瘤，否则就需要进行广泛的手术。本文概述了自20世纪初以来形成该技术的基础历史工作。创新的光敏剂和微调提高了肿瘤的选择性，也提高了PDT的疗效。本文综述了治疗过程中的不良反应和治疗，以及基于pdp的创新应用。最后，PDT研究差距和临床试验已被确定为潜在问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.