STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INTERACTIONS BETWEEN MEDICAL POLYMERS AND THE LIPOSOMS AND BACTERIAL CELLS

Abstract

Polymers are widely applied as drug delivery systems and implant coatings. The review is devoted to the mechanisms of interaction of biomedical polymers with model cell membranes (liposomes) and real biological objects - bacterial cell surfaces. A comparative analysis of the composition, structure and surface charge of different types of biological membranes has been outlined. We consider the main methods and approaches for studying the effect of polymers on the structure and physico-chemical properties of membranes to uncover adsorption, defects in the bilayer, violations of the integrity of the bilayer, changes in cell morphology, etc. The correlation between the observed effects on model and real objects is analyzed. One of the important tasks of the review is to discover the key polymer’s characteristic (structure, size, charge, etc.) for the design of new high-molecular compounds with specified biological properties.