Effect of Andrographis paniculata Extracts on Regeneration and Prevention of Oxidative Stress Damage in Planaria

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2023-10-21 DOI:10.1080/10496475.2023.2271416

Sadik Aref

引用次数: 0

Abstract

ABSTRACTThis study explored the potential of Andrographis paniculata in regulating redox imbalance using planaria as a model organism. Decapitated planaria were regenerated in water, A. paniculata extract, hydrogen peroxide, and a combination of hydrogen peroxide and A. paniculata. The growth was 26% higher, locomotion 15% higher, and protein 35% higher in A. paniculata group. The stressed group had 33% higher growth, 17% higher locomotion, and 36% higher protein when treated with A. paniculata. In conclusion, A. paniculata accelerated the regeneration and minimized the stress induced by hydrogen peroxide and hence can be a promising option for the prevention of neurodegenerative diseases.KEYWORDS: Andrographolideplanariaredox Disclosure statementNo potential conflict of interest was reported by the author(s).

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穿心莲提取物对涡虫再生及抗氧化应激损伤的作用

摘要本研究以涡虫为模式生物，探讨穿心莲调节氧化还原失衡的潜力。将无头涡虫分别在水、金针菇提取物、双氧水和双氧水与金针菇的混合液中再生。长势提高26%，运动能力提高15%，蛋白质含量提高35%。应激组的生长比对照组高33%，运动比对照组高17%，蛋白质比对照组高36%。综上所述，金针叶能加速神经细胞的再生，减少过氧化氢诱导的应激，因此可以作为预防神经退行性疾病的有希望的选择。披露声明作者未报告潜在的利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.