Alginate-ZnO-Poly(ethylene glycol) dimethacrylate (PEGDMA) via Interpenetrating Polymer Network as a Functional Material for Wound Dressing

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

INDONESIAN JOURNAL OF PHARMACY Pub Date : 2023-09-04 DOI:10.22146/ijp.5388

Ane Nurjanah, Muhammad Bachri Amran, Rusnadi Rusnadi

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Abstract

Alginate is a biopolymer that has been widely applied as a wound dressing material. To increase the mechanical and antibacterial properties of a wound dressing material, nanoparticles and synthetic polymers are used to modify alginate. One of the materials synthesized into nanoparticles is ZnO, which has potential applications in the medical field because of its good antibacterial properties. On the other hand, PEGDMA has not been widely used in the medical field, opening opportunities to develop research, especially regarding wound dressing materials. However, there has never been a detailed report on the modification of alginate using ZnO and PEGDMA. In this paper, alginate was modified using ZnO and poly(ethylene glycol) dimethacrylate (PEGDMA; alginate–ZnO–PEGDMA, AZP), which was synthesized using the Interpenetrating Polymer Network (IPN) method. AZP can increase a wound dressing material’s mechanical properties by 78% and the antibacterial properties by 94%, which indicates that alginate modification with ZnO and PEGDMA produces high-performance wound dressing materials.

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海藻酸盐- zno -聚乙二醇二甲基丙烯酸酯(PEGDMA)互穿聚合物网络作为伤口敷料的功能材料

海藻酸盐是一种生物聚合物，已广泛应用于伤口敷料。为了提高伤口敷料的机械性能和抗菌性能，纳米颗粒和合成聚合物被用来修饰海藻酸盐。合成纳米颗粒的材料之一是氧化锌，由于其良好的抗菌性能，在医学领域具有潜在的应用前景。另一方面，PEGDMA尚未在医疗领域得到广泛应用，这为发展研究提供了机会，特别是在伤口敷料方面。然而，利用ZnO和PEGDMA对海藻酸盐进行改性的研究尚未见详细报道。本文采用ZnO和聚乙二醇二甲基丙烯酸酯(PEGDMA)对海藻酸盐进行了改性;海藻酸盐- zno - pegdma, AZP)，采用互穿聚合物网络(IPN)法合成。AZP可使创面敷料的力学性能提高78%，抗菌性能提高94%，表明海藻酸盐经ZnO和PEGDMA改性制备出高性能创面敷料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.