Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy: a precise construction of structurally diverse azaspiro polycyclic scaffolds

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2023-10-23 DOI:10.1007/s11426-023-1782-9

Xiao-Bao Wu, Jun-Xiu Shi, Yi-Ming Ou, Hua-Jie Jiang, Yi-Jun Fang, Qi-Ming Wang, Quan Gao, Jie Yu

引用次数: 0

Abstract

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds. Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results (up to 99:1 e.r., >95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(III) complexes.

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顺序对映选择性 Ugi-4CR/post-Ugi 转化策略：精确构建结构多样的氮杂环多环支架

为精确构建对映体丰富的氮杂环多环支架，我们开发了一种独特的策略。在阴离子立体钴（III）络合物存在下，通过与含有先决官能团的底物进行顺序对映选择性四组份乌基反应/后乌基转化，获得了具有多个连续立体中心的结构多样的氮杂环多环，并取得了优异的结果（最高可达 99:1 e.r.，>95:5 d.r.）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.