Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment

IF 3.2 3区医学 Q3 CELL & TISSUE ENGINEERING

European cells & materials Pub Date : 2023-11-07 DOI:10.22203/ecm.v046a04

LT Laagland, FC Bach, FM Riemers, G Erdmann, TS Braun, GGH van den Akker, TC Schmitz, LB Creemers, C Sachse, CL Le Maitre, TJM Welting, K Ito, MF Templin, MA Tryfonidou

引用次数: 0

Abstract

Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the nucleus pulposus shifts from notochordal cells (NCs) to nucleus pulposus cells (NPCs). In previous studies, porcine NC-derived matrix (NCM), containing NC-secreted factors, induced matrix anabolic effects and inhibited pro-inflammatory mediators in NPCs in vitro and in degenerated

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脊索细胞衍生基质在椎间盘退行性环境中抑制MAPK信号

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来源期刊

European cells & materials 生物-材料科学：生物材料

CiteScore

6.00

自引率

6.50%

发文量

审稿时长

1.5 months

期刊介绍： eCM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Trauma, Maxillofacial (including dental), Spine and Orthopaedics). The clinical relevance of the work must be briefly mentioned within the abstract, and in more detail in the paper. Poor abstracts which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by eCM journal.Cross-disciplinary papers that go across our scope areas are welcomed.