Development and Greenness Assessment of Analytical Quality by Design Optimised Eco-friendly UV Spectrophotometric Methods for Analysis of Two Natural Antioxidants in Pure and Formulation

Q4 Pharmacology, Toxicology and Pharmaceutics
Ramya Jonnalagadda, Seetharaman Rathinam, Vinodhini Chandrasekar
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引用次数: 0

Abstract

Utilizing analytical quality by design and green analytical chemistry principles, the present work introduces simple, robust, and environmentally benign UV methods. Two separate spectrophotometric methods were developed for the estimation of Silybin and Curcumin, where solvent, scan speed, and sampling interval are the estimated critical parameters. The detection was carried out at absorption maxima of 288nm for Silybin and 419nm for Curcumin with ethanol. To determine the critical method variables, a risk assessment was carried out using an Ishikawa diagram. Developed spectrophotometric methods were validated according to the International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Q2 (R1) guidelines. The proposed methods showed good predictability and robustness. The new methodologies were found to be green according to the analytical greenness metric approach and software, the green analytical procedure index, and analytical eco-scale tools in comparison to the existing methods.
设计优化紫外分光光度法分析两种天然抗氧化剂纯品和制剂的分析质量及绿色评价
利用设计分析质量和绿色分析化学原理,本工作介绍了简单、可靠、环保的紫外检测方法。建立了测定水飞蓟宾和姜黄素的两种不同的分光光度法,其中溶剂、扫描速度和采样间隔是估计的关键参数。在乙醇条件下,水飞蓟宾和姜黄素的最大吸收波长分别为288nm和419nm。为了确定关键的方法变量,使用石川图进行了风险评估。根据国际人用药品注册技术要求协调委员会Q2 (R1)指南对开发的分光光度法进行了验证。该方法具有良好的可预测性和鲁棒性。与现有方法相比,根据分析绿色度量方法和软件、绿色分析程序指数和分析生态尺度工具,发现新方法是绿色的。
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来源期刊
Journal of Natural Remedies
Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
27
期刊介绍: Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.
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