Comparative Study of Chemical Composition and Cholinesterase Inhibition Potential of Essential Oils Isolated from Artemisia Plants from Croatia

IF 2.5 4区工程技术 Q3 CHEMISTRY, ANALYTICAL

Separations Pub Date : 2023-10-23 DOI:10.3390/separations10100546

Olivera Politeo, Ivana Cajic, Anja Simic, Mirko Ruscic, Mejra Bektasevic

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Abstract

The essential oil (EO) of Artemisia plants contains a large number of bioactive compounds that are widely used. The aim of this study was to analyse the chemical composition of EOs of six Artemisia plants collected in Croatia and to test their cholinesterase inhibitory potential. GC–MS analysis of the EO of A. absinthium showed that the dominant compounds are cis-sabinyl acetate and cis-epoxy-ocimene; in EO of A. abrotanum, it is borneol; in the EO of A. annua, they are artemisia ketone, camphor and 1,8-cineole; in the EO of A. arborescens, they are camphor and chamazulene; in the EO of A. verlotiorum, they are cis-thujone, 1,8-cineole and trans-thujone; and in the EO of A. vulgaris, they are trans-thujone and trans-epoxy-ocimene. The EO of the five studied Artemisia species from Croatia is rich in monoterpenoid compounds (1,8-cineole, artemisia ketone, cis-thujone, trans-thujone, cis-epoxy-ocimene, camphor, borneol and cis-sabinyl acetate). The EO of A. arborescens is also rich in chamazulene. The results also showed that the tested EOs have moderate cholinesterase inhibition potential, especially the EOs of A. annua, A. vulgaris and A. abrotanum. This is the first analysis of the chemical composition of the EOs of four Artemisia plants and the first analysis of cholinesterase potential for plants collected in Croatia.

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克罗地亚蒿属植物精油化学成分及抑制胆碱酯酶活性的比较研究

青蒿属植物精油中含有大量生物活性化合物，被广泛应用。本研究的目的是分析在克罗地亚采集的6种青蒿属植物的化学成分，并测试它们的胆碱酯酶抑制潜力。气相色谱-质谱分析表明，苦艾草的主要成分为顺式乙酸松木酯和顺式环氧辛烯;黄芩的EO为冰片;黄花蒿的主要成分为青蒿酮、樟脑和1,8-桉树脑;在杉木的EO中，它们是樟脑和chamazulene;在白莲的EO中，它们是顺式图琼、1,8-桉叶脑和反式图琼;在寻常草的EO中，它们是反式叔丁烯和反式环氧-辛烯。所研究的克罗地亚五种青蒿的EO富含单萜类化合物(1,8-桉树脑、青蒿酮、顺式图琼、反式图琼、顺式环氧-辛烯、樟脑、龙脑和顺式乙酸松香酯)。叶竹的EO中也含有丰富的chamazulene。实验结果还表明，所测黄芪提取物对胆碱酯酶有中等抑制作用，特别是黄芪、黄芪和黄芪提取物。这是对四种青蒿属植物的化学成分的首次分析，也是对克罗地亚收集的植物的胆碱酯酶潜力的首次分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Separations Chemistry-Analytical Chemistry

CiteScore

3.00

自引率

15.40%

发文量

342

审稿时长

12 weeks

期刊介绍： Separations (formerly Chromatography, ISSN 2227-9075, CODEN: CHROBV) provides an advanced forum for separation and purification science and technology in all areas of chemical, biological and physical science. It publishes reviews, regular research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal: Manuscripts regarding research proposals and research ideas will be particularly welcomed. Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Manuscripts concerning summaries and surveys on research cooperation and projects (that are funded by national governments) to give information for a broad field of users. The scope of the journal includes but is not limited to: Theory and methodology (theory of separation methods, sample preparation, instrumental and column developments, new separation methodologies, etc.) Equipment and techniques, novel hyphenated analytical solutions (significantly extended by their combination with spectroscopic methods and in particular, mass spectrometry) Novel analysis approaches and applications to solve analytical challenges which utilize chromatographic separations as a key step in the overall solution Computational modelling of separations for the purpose of fundamental understanding and/or chromatographic optimization