Serum Evaluation of Human T-lymphotropic Virus Type 1 and 2 (HTLV-I/II) and Human Immunodeficiency Virus (HIV) in Patients with Multiple Sclerosis (MS)

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2023-09-28 DOI:10.5812/ans-135230

Zahra Golmohammadi, Reza Boostani, Morteza Saeidi, Ehsan Aryan, Aida Gholoobi, Mojtaba Meshkat, Amin Hooshyar Chechaklou, Mahdieh Khoshakhlagh, Samaneh Abolbashari, Zahra Meshkat

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Abstract

Background: Multiple Sclerosis (MS) is a multifactorial disease that causes neurological disability. Human retroviruses may have a role in the etiology of several acute and chronic neurological disorders. Objectives: We aimed to investigate the presence of HTLV-I/II and HIV antibodies in the sera of MS patients to assess the relationship between these infections and MS. Methods: This case-control study was conducted on serum samples of MS patients and individuals admitted to the same hospital with no symptoms of MS as the control group. Samples were examined for HIV and HTLV-I/II antibodies using ELISA kits. Results: A total of 79 people, including 38 MS patients and 41 healthy individuals, were evaluated. The frequency of HIV antibodies was 0.0% in both the case and control groups. The HTLV-I/II antibodies were detected in 1 patient in the control group and no patients in the MS group, with no statistically significant difference between the two groups (P: 0.999). Conclusions: This study could not establish a relationship between the presence of HTLV-I/II or HIV antibodies and MS.

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多发性硬化症(MS)患者血清嗜t淋巴病毒1型和2型(HTLV-I/II)和人类免疫缺陷病毒(HIV)的检测

背景:多发性硬化症(MS)是一种导致神经功能障碍的多因素疾病。人类逆转录病毒可能在几种急性和慢性神经系统疾病的病因学中起作用。目的:研究多发性硬化症患者血清中HTLV-I/II和HIV抗体的存在情况，以评估这些感染与多发性硬化症之间的关系。方法:本病例对照研究采用多发性硬化症患者和同一医院住院的无多发性硬化症患者的血清样本作为对照组。使用ELISA试剂盒检测样品的HIV和HTLV-I/II抗体。结果:共评估79人，其中MS患者38人，健康个体41人。病例组和对照组的HIV抗体阳性率均为0.0%。对照组1例患者检测到HTLV-I/II抗体，MS组无患者检测到HTLV-I/II抗体，两组比较差异无统计学意义(P: 0.999)。结论:本研究不能建立HTLV-I/II或HIV抗体与MS之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.