Exploring the Prognostic and Predictive Roles of Ki-67 in Endometrial Cancer

Journal of International Translational Medicine Pub Date : 2023-11-01 DOI:10.3390/ijtm3040033

Laura Paleari, Mariangela Rutigliani, Oriana D’Ecclesiis, Sara Gandini, Irene Maria Briata, Tania Buttiron Webber, Nicoletta Provinciali, Andrea DeCensi

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Abstract

Background: Up to now, endometrial cancer (EC) treatments are mainly represented by surgery followed by adjuvant chemotherapy or radiotherapy. The updated guidelines give a 2A recommendation for the use of hormone therapy only in advanced low-grade ECs, underlying the need for more data on the role of hormone therapy in the adjuvant setting. Methods: The clinicopathological data of 158 early-stage EC patients was retrospectively collected. A Ki-67 cut-off value of 40% was established based on literature data. Disease-free survival (DFS) and Overall survival (OS) were evaluated. Results: Results: Multivariate analysis of DFS and OS showed a significantly increased risk of progression in patients with >40% Ki-67 [HR = 3.13 (95% CI; 1.35–7.14); p = 0.007] and a significantly higher relative risk of death [HR = 3.70 (95% CI; 1.69–8.33); p = 0.001]. The predictive role of the Ki-67 index was highlighted by the clinical benefit of adjuvant hormone in patients with high Ki-67. Conclusions: Our results suggest a positive role of the Ki-67 index as a prognostic and potentially predictive marker in EC, although further studies are warranted to reach a definitive conclusion.

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探讨Ki-67在子宫内膜癌中的预后和预测作用

背景:目前，子宫内膜癌(EC)的治疗以手术加辅助化疗或放疗为主。更新后的指南建议仅在晚期低级别ECs中使用激素治疗，这表明需要更多关于激素治疗在辅助治疗中的作用的数据。方法:回顾性收集158例早期EC患者的临床病理资料。根据文献资料，Ki-67临界值为40%。评估无病生存期(DFS)和总生存期(OS)。结果:结果:DFS和OS的多因素分析显示，>40% Ki-67患者的进展风险显著增加[HR = 3.13 (95% CI;1.35 - -7.14);p = 0.007]和显著较高的相对死亡风险[HR = 3.70 (95% CI;1.69 - -8.33);P = 0.001]。辅助激素在高Ki-67患者中的临床获益强调了Ki-67指数的预测作用。结论:我们的研究结果表明Ki-67指数作为EC的预后和潜在预测指标具有积极作用，尽管需要进一步的研究才能得出明确的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.